RRML - Bacterial pneumonia – frequency of occurrence and antimicrobial susceptibility of bacterial isolates
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Dr. Adrian Man

   
 
Nr. 2(1)/2006
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Bacterial pneumonia – frequency of occurrence and antimicrobial susceptibility of bacterial isolates

Felicia Toma, Doina Bilca, Delia Pârvu, Teodora Cighir, Monica Tarcea


Abstract:

Our objective was to determine the frequency of occurrence and antimicrobial susceptibility of bacterial isolates collected from hospitalized patients with pneumonia in Mures county. 965 bacterial strains were collected between 2000 and 2003, which were identified by the routine methodology in use at each laboratory. Antimicrobial susceptibility testing was performed and interpreted following the guidelines for reference broth microdilution [NCCLS 2000]. The most frequently isolated species were: P. aeruginosa (32.3%), S. aureus (32.1%), K. pneumoniae (12.4%), Acinetobacter spp. (11.4%), Enterobacter (6.7), H. influenzae (5%). The most active agents against P. aeruginosa were meropenem (CMI 1 μg/ml; 71.5%) and amikacin (CMI 4 μg/ml; 71.2%). The prevalence of meticillin resistant S. aureus (MRSA) was 47.1%, vancomycin, teicoplanin and linezolide being the most active drugs against this pathogen. Imipenem, meropenem and tetracycline were the most active agents against Acinetobacter spp. (83.6%, 85.5% respectiv 51.8% susceptible strain). Approximately 35% of K. pneumoniae isolates were considered extended spectrum beta lactamase (ESBL) producers. Respiratory tract pathogens isolated from patients hospitalized with pneumonia were multidrug resistant. A local surveillance program is necessary for correctly guiding empiric therapy.

Keywords: bacterial pneumonia,antimicrobial resistance,hospitalized patients

 
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How to cite
Toma F, Bilca D, Pârvu D, Cighir T, Tarcea M. Bacterial pneumonia – frequency of occurrence and antimicrobial susceptibility of bacterial isolates. Rev Romana Med Lab. 2006;2(1):42-7