RRML - Application of Cytogenetics for Chronic Myeloid Leukemia in Tîrgu Mureş

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Nr. 14(1)/2009

Application of Cytogenetics for Chronic Myeloid Leukemia in Tîrgu Mureş

Claudia Bănescu, István Benedek, Erzsébet Benedek, Ionela Paşcanu, Katalin Csép, Carmen Duicu, Smaranda Demian

Abstract:

Chronic myeloid leukaemia (CML) is a myeloproliferative disorder characterized in about 95% of cases by the presence of the Philadelphia (Ph) chromosome, which results from a reciprocal translocation between chromosomes 9 and 22, t(9;22)(q34;q11). Our aim was to identify and to evaluate the frequency of chromosomal abnormalities at the time of diagnosis and during drug therapy for monitoring treatment response in patients with CML in the Hematology Clinic in Tîrgu Mureş. Between January 2006 and January 2009 we received for chromosomal analysis 52 samples of bone marrow and/or peripheral blood from CML patients from the Hematology Clinics from Tîrgu Mureş. We carried out bone marrow and/or peripheral blood cell culture according to standard methods. We successfully analyzed the leukemic karyotype of 46 patients (88,5%) and identified 25 (54,3%) cases with chromosomal abnormalities. Analyses performed on the bone marrow at the moment of CML diagnosis confirmed the presence of Ph chromosome t(9;22)(q34q11), in 92% of patients. 37 cases with CML were cytogenetically analysed during drug therapy for monitoring treatment response. During therapy 20 patients were Ph negative and seven had different level of cytogenetic response.

Keywords: chronic myeloid leukemia,cytogenetic,Philadelphia chromosome

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Bănescu C, Benedek I, Benedek E, Paşcanu I, Csép K, Duicu C, et al. Application of Cytogenetics for Chronic Myeloid Leukemia in Tîrgu Mureş. Rev Romana Med Lab. 2009;14(1):31-9