RRML - Endothelin-1 plasma concentration in patients with essential hypertension, atherogenic dyslipidemia and coronary artery disease
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Dr. Adrian Man
   
 
Nr. 18(4)/2010
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Endothelin-1 plasma concentration in patients with essential hypertension, atherogenic dyslipidemia and coronary artery disease

Germaine Săvoiu, Carmen Cristescu, Corina Şerban, Lavinia Noveanu, Claudia Borza, Cristina Dehelean, Mihaela Andoni, Minodora Andor, Ovidiu Fira-Mlădinescu


Abstract:

The aim of this study was to investigate endothelin-1 (ET-1) plasma concentration in patients with essential hypertension, atherogenic dyslipidemia, and coronary artery disease confirmed by coronarography and the relationship between ET-1 and subclinical atherosclerosis. The study comprised 32 patients with coronary artery disease, 12 hypertensive, 12 with atherogenic dyslipidemia and 12 healthy subjects. Antihypertensive medication was interrupted for two weeks before the study. The concentration of ET-1 was measured by ELISA. Endothelium-dependent, flow-mediated dilatation (FMD) of the brachial artery and carotid intima-media thickness (IMT) of the carotid artery were assessed by B-mode ultrasonography. ET-1 plasma concentration was significantly higher (p < 0.001) in coronary artery disease patients (25  5.42 pg/ml) comparative with atherogenic dyslipidemia patients (19  5.63 pg/ml), with hypertensive patients (16.8  5.16 pg/ml) and with the control subjects (7.2  2.53 pg/ml). A significant negative correlation was found between ET-1 and FMD of the brachial artery in coronary artery disease patients (r = -0.81, p < 0.001), in hypertensive patients (r = -0.82, p < 0.001), atherogenic dyslipidemia patients (r = -0.85, p < 0.001), and control subjects (r= -0.84, p < 0.001). A positive significant correlation between ET-1 and carotid IMT was found only in coronary artery disease patients (r = 0.57, p<0.001). We did not find significant correlations between endothelin-1 and carotid IMT in hypertensive (r = 0.10, p=0.08), dyslipidemic (r = - 0.10, p=0.06) patients, and control subjects (r = - 0.14, p=0.03).

Keywords: endothelin-1,IMT,FMD

 
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How to cite
Săvoiu G, Cristescu C, Şerban C, Noveanu L, Borza C, Dehelean C, et al. Endothelin-1 plasma concentration in patients with essential hypertension, atherogenic dyslipidemia and coronary artery disease . Rev Romana Med Lab. 2010;18(4):25-30