RRML - Effect of polycyclic aromatic hydrocarbons on some clinical parameters in case of patients with lung cancer and associated diagnostics
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Dr. Adrian Man
   
 
Nr. 19(1)/2011
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Effect of polycyclic aromatic hydrocarbons on some clinical parameters in case of patients with lung cancer and associated diagnostics

Mona E. Cioroiu, Doina Tarcău, Simona Cucu Man, Bogdan I. Cioroiu, Raluca, Irina Chisăliţă


Abstract:

Tobacco smoke and environmental pollutants represent the first risk factors in case of lung cancer. The aim of this study was to investigate associations between polycyclic aromatic hydrocarbons (PAHs) levels in human lung tissue and modifications of serum and blood clinical parameters in patients with pulmonary cancer and associated diagnostics such as diabetes, HTN and anemia. This study included 31 histologically confirmed lung cancer cases diagnosed consecutively in the Clinical Hospital of Pneumology Iasi from 2008 to 2009. Analyses were carried out using accelerated solvent extraction technique and HPLC with a fluorescence detector. Higher concentrations of non carcinogenic PAHs (ΣPAHs =79.96 ng/g wet tissue) and carcinogenic PAHs (ΣPAHs = 7.72 ng/g wet tissue) were found in patients with HTN as secondary diagnosis, followed by patients with diabetes (non carcinogenic ΣPAHs = 57.71 ng/g wet tissue, carcinogenic ΣPAHs =3.18 ng/g wet tissue) and anemia (non carcinogenic ΣPAHs = 32.47 ng/g wet tissue, carcinogenic ΣPAHs = 5.86 ng/g wet tissue). RBC, HCT and HGB values were low for 65% of the investigated subjects, and also were positively correlated (p<0.05) with levels of benzo(g,h,i)perylene in lung tissue. Serum C reactive protein and plasma fibrinogen exceed the reference values proposed by the clinical laboratory and were positively correlated with benzo(a)anthracene and fluorene.

Keywords: Pollution,lung cancer,BaPy,RBC,CRP

 
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How to cite
Cioroiu ME, Tarcău D, Cucu Man S, Cioroiu BI, Raluca , Chisăliţă I. Effect of polycyclic aromatic hydrocarbons on some clinical parameters in case of patients with lung cancer and associated diagnostics. Rev Romana Med Lab. 2011;19(1):55-64