RRML - Influenza vaccine effectiveness to prevent medically attended laboratory confirmed influenza during season 2010-2011 in Romania: a case control study

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Nr. 20(2)/2012

Influenza vaccine effectiveness to prevent medically attended laboratory confirmed influenza during season 2010-2011 in Romania: a case control study

Daniela Pitigoi, Alina Elena Ivanciuc, Gheorghe Necula, Emilia Lupulescu, Viorel Alexandrescu, Camelia Savulescu

Abstract:

We aimed to measure the seasonal trivalent influenza vaccine effectiveness against medically attended, laboratory confirmed influenza in Romania through a test-negative case-control study, part of ECDC-funded I-MOVE project. We included in the study 154 cases and 101 test-negative controls. We identified seven (4.5%) vaccine failures and 13 (12.9%) vaccinated controls. The overall adjusted vaccine effectiveness was 83% (95% confidence interval (CI): 23, 96), and 78.0% (95% CI: -119, 98) in the target group for vaccination. The results suggest a good protection of the 2010-2011 seasonal influenza vaccine against medically-attended laboratory confirmed influenza in Romania, taking into account the several limitations of the study. The participation in the I-MOVE multicentre case-control study allowed conducting the vaccine effectiveness study in Romania

Keywords: Influenza,vaccine effectiveness,case-control

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Pitigoi D, Ivanciuc AE, Necula G, Lupulescu E, Alexandrescu V, Savulescu C. Influenza vaccine effectiveness to prevent medically attended laboratory confirmed influenza during season 2010-2011 in Romania: a case control study. Rev Romana Med Lab. 2012;20(2):127-34