RRML - Hepatocellular carcinoma a retrospective clinico-pathologic and immunohistochemical study of 15 cases
AMLR

ISSN online: 2284-5623

ISSN-L: 1841-6624

Rejection rate (2020): 75%

Română English

Journal Metrics

Impact Factor 0.5
Five Year Impact Factor 0.5
JCI 0.12

Advanced search

Top 10 downloaded articles
- April 2024 -
 
A comprehensive review of Prof... 24
Recomandarea comună EFLM-COLA... 14
Monocyte to high-density lipop... 10
Anti-thyroid peroxidase (TPO) ... 10
Understanding the key differen... 9
Understanding the pathogenesis... 7
Romanian Review of Laboratory ... 6
Function of the S1P pathway in... 6
Predictive value of expression... 6
The importance of tumor marker... 5

Log in

Concept, Design & Programming
Dr. Adrian Man
   
 
Nr. 21(4)/2013 DOI:10.2478/rrlm-2013-0036
XML
TXT

Hepatocellular carcinoma a retrospective clinico-pathologic and immunohistochemical study of 15 cases

Cristiana Iulia Dumitrescu, Daniela Dumitrescu, Daniela Cernea, Corneliu-Cristian Georgescu, Claudiu Margaritescu


Abstract:

Hepatocellular carcinoma (HCC) is the fifth most frequently diagnosed cancer worldwide, and the third most frequent oncological cause of death. Being detected at an advanced, non-resectable stage, HCC is associated with a low 5-year survival and poor prognosis. Recently some studies have demonstrated that the prognosis of HCC correlates to various molecular markers. In this view, we have studied here the immunohistochemical reactivity of 15 HCC cases diagnosed in the last three years for some biomarkers with prognostic value such as p53, alpha-fetoprotein (AFP) and CXCR4, in correlation with the major clinicopathological parameters of these patients. In our casuistry the most prevalent architectural pattern was the trabecular (53.4%), followed by the pseudoglandular pattern (20%), while the less common diagnosed were the solid and pleomorphic variants. More than 80% of these tumors were well to moderate differentiated; developed in the six decade, twice more common in men and diagnosed in advance stages (80% of cases in stages ≥III). Markers such as CK18, CK7 and CEA were usefully in order to certify the primary liver origin and the hepatocellular differentiation of these tumors. Moreover, biomarkers as p53, AFP and CXCR4 were positive especially in more advance stages suggesting the possibility of their utilization as prognostic factors and in the therapeutically stratification of such patients.

Keywords: hepatocellular carcinoma,immunohistochemistry,pleomorphic,pseudoglandular,solid,trabecular

 
  PDF Download full text PDF
(544 KB)
     
 
How to cite
Dumitrescu CI, Dumitrescu D, Cernea D, Georgescu CC, Margaritescu C. Hepatocellular carcinoma a retrospective clinico-pathologic and immunohistochemical study of 15 cases. Rev Romana Med Lab. 2013;21(4):453-63. DOI:10.2478/rrlm-2013-0036