RRML - The role of inflammation and Chlamydia pneumoniae infection in patients with chronic occlusion of the terminal aorta
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Nr. 12(3)/2008
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The role of inflammation and Chlamydia pneumoniae infection in patients with chronic occlusion of the terminal aorta

Ioan Țilea, Brîndușa Țilea, Grațiela Tripon, Cristina Maria Tatar, RC Serban, H. Suciu, Alina Scridon


Abstract:

Background: Chronic Chlamydia pneumoniae (CP) and cytomegalic virus (CMV) infections are considered important risk factors for atherosclerosis, but without a certain benefit from the antimicrobial therapy. Infection has yet an unknown role in the appearance and progression of peripheral arterial disease (PAD) that is why conventional therapy for PAD does not include antimicrobial treatment. Aim: to investigate the association of inflammation and Chlamydia pneumoniae infection with the presence of chronic aortic occlusion (Leriche syndrome). Methods: A number of 122 subjects, divided into two groups, were assessed using clinical criteria, laboratory findings and invasive imaging (classic angiography +/- digital subtraction angiography). The study group included 62 patients with Leriche syndrome. The diagnostic inclusion criteria were the classic ones and the angiographic presence of Leriche syndrome. The control group included 60 patients without any cardiovascular pathology, recruited from general population. C reactive protein (CRP), fibrinogen and specific antibodies for Chlamydia pneumoniae, IgM and IgG presence were determined for both groups. Results: A higher incidence of serological evidence of CP infection was found in the patients from the study group (43/62) than in controls (6/60). There is no statistically association between serological evidence of CP infection and age, provenience, or smoking. In the study group 28 patients had fibrinogen values over 400 mg% compared to just 2 patients in the control group and also 28 patients had high levels of CRP compared to just 2 in control group. CRP (p=0.003), IgG (p=0.011) and fibrinogen were significantly correlated with severe stages of chronic aortic occlusion. Conclusions: This study supports the hypothesis that inflammation (high levels of CRP, fibrinogen) and chronic CP infection (IgG seropositivity) have an important role in lower limb atherosclerosis and correlate with the severity of the disease.

Keywords: chronic aortic occlusion,inflammation,Chlamydia pneumonia,atherosclerosis

 
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How to cite
Țilea I, Țilea B, Tripon G, Tatar CM, Serban R, Suciu H, et al. The role of inflammation and Chlamydia pneumoniae infection in patients with chronic occlusion of the terminal aorta. Rev Romana Med Lab. 2008;12(3):31-6