RRML - Fatal sepsis due to community-associated methicillin-resistant Staphylococcus aureus – a case report
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Nr. 18(2)/2010
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Fatal sepsis due to community-associated methicillin-resistant Staphylococcus aureus – a case report

Edit Székely, Liviu Sorin, Simona Marinescu, Erika Ungvári, Ákos Tóth , Judit Pászti


Abstract:

We present the case of a community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) infection, which led to a rapidly evolving fatal sepsis with necrotizing pneumonia in a four year old girl. The patient was admitted to the Mures County Emergency Clinical Hospital at 7:50 a.m. on the 15th of March 2007. A few days before presentation the girl had suffered a minor trauma of her left heel. According to clinical, biochemical and radiological findings, septic shock with cutaneous origin, cellulitis of the left heel and bilateral pneumonia were diagnosed. She received intravenous fluid resuscitation and large spectrum antibiotic therapy was started. Later that day, the patient’s condition deteriorated and she went on a cardiorespiratory stop and died at 03:25 p.m. On autopsy, bilateral necrotizing pneumonia was documented. MRSA was isolated from blood cultures. Based on epidemiological data and on phenotypical and molecular characterization, the strain was found to be a CA-MRSA harboring SCCmec type IV and Panton Valentine leukocidin genes which belonged to spa type t044. This was the first and so far only case of fatal sepsis occurring in our hospital due to CA-MRSA strain confirmed by means of molecular techniques. The dramatic rapidity of its evolution represents a major concern and demonstrates the extreme virulence and harming capacity of this type of CA-MRSA.

Keywords: pneumonia,Panton-Valentine leukocidin,bacterial typing

 
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How to cite
Székely E, Sorin L, Marinescu S, Ungvári E, Á, Pászti J. Fatal sepsis due to community-associated methicillin-resistant Staphylococcus aureus – a case report. Rev Romana Med Lab. 2010;18(2):29-33