RRML - Aspects regarding intratumor angiogenesis and vasculogenic mimicry in canine mammary tumors

Main page
News
RJLabM Credits
Archive
- Current issue
- Ahead of print
- List of published issues
- 2024
  - Nr.1/2024
- 2023
  - Nr.4/2023
  - Nr.3/2023
  - Nr.2/2023
  - Nr.1/2023
  - Supplement 1/2023
- 2022
  - Nr.4/2022
  - Nr.3/2022
  - Nr.2/2022
  - Nr.1/2022
  - Supplement 1/2022
- 2021
  - Nr.4/2021
  - Nr.3/2021
  - Nr.2/2021
  - Nr.1/2021
- 2020
  - Nr.4/2020
  - Nr.3/2020
  - Nr.2/2020
  - Nr.1/2020
  - Supplement 1/2020
- 2019
  - Nr.4/2019
  - Nr.3/2019
  - Nr.2/2019
  - Nr.1/2019
  - Supplement 1/2019
- 2018
  - Nr.4/2018
  - Nr.3/2018
  - Nr.2/2018
  - Nr.1/2018
  - Supplement 1/2018
  - Supplement 2/2018
  - Supplement 3/2018
- 2017
  - Nr.4/2017
  - Nr.3/2017
  - Nr.2/2017
  - Nr.1/2017
  - Supplement 1/2017
- 2016
  - Nr.4/2016
  - Nr.3/2016
  - Nr.2/2016
  - Nr.1/2016
  - Supplement 1/2016
- 2015
  - Nr.4/2015
  - Nr.3/2015
  - Nr.2/2015
  - Nr.1/2015
  - Supplement 1/2015
- 2014
  - Nr.4/2014
  - Nr.3/2014
  - Nr.2/2014
  - Nr.1/2014
  - Supplement 1/2014
- 2013
  - Nr.4/2013
  - Nr.3/2013
  - Nr.2/2013
  - Nr.1/2013
  - Supplement 1/2013
- 2012
  - Nr.4/2012
  - Nr.3/2012
  - Nr.2/2012
  - Nr.1/2012
  - Supplement 1/2012
- 2011
  - Nr.4/2011
  - Nr.3/2011
  - Nr.2/2011
  - Nr.1/2011
  - Supplement 1/2011
- 2010
  - Nr.4/2010
  - Nr.3/2010
  - Nr.2/2010
  - Nr.1/2010
  - Supplement 1/2010
- 2009
  - Nr.4/2009
  - Nr.3/2009
  - Nr.2/2009
  - Nr.1/2009
  - Supplement 1/2009
- 2008
  - Nr.4/2008
  - Nr.3/2008
  - Nr.2/2008
  - Nr.1/2008
  - Supplement 1/2008
- 2007
  - Nr.4/2007
  - Nr.3/2007
  - Nr.2/2007
  - Nr.1/2007
- 2006
  - Nr.4/2006
  - Nr.3/2006
  - Nr.2/2006
  - Nr.1/2006
- 2005
  - Nr.1/2005
Instructions for authors
Online applications
- Send an article
- Online payments
Editorial
About us
Links

ISSN online: 2284-5623

ISSN-L: 1841-6624

Rejection rate (2020): 75%

Journal Metrics

Impact Factor 0.5
Five Year Impact Factor 0.5
JCI 0.12

Top 10 downloaded articles - April 2024 -

A comprehensive review of Prof...	25
Recomandarea comună EFLM-COLA...	15
Anti-thyroid peroxidase (TPO) ...	11
Understanding the key differen...	10
Monocyte to high-density lipop...	10
Romanian Review of Laboratory ...	7
Understanding the pathogenesis...	7
Predictive value of expression...	7
Approaching Risk Management in...	6
Function of the S1P pathway in...	6

Concept, Design & Programming
Dr. Adrian Man

Nr. 19(3)/2011

Aspects regarding intratumor angiogenesis and vasculogenic mimicry in canine mammary tumors

Adrian F. Gal, Alecsandru I. Baba, Viorel Miclaus, Adriana Titilincu, Cosmina Cuc, Marian Taulescu, Cornel Catoi

Abstract:

Canine mammary tumors represent an important cause of morbidity and mortality in female dogs worldwide having a three times higher frequency than breast cancer in women. Neo-angiogenesis is critical for tumor growth, progression and metastases. The purpose of this study was to investigate neo-angiogenesis in canine mammary tumors and its possible utility as a prognostic biomarker by comparison with classic prognostic factors. In addition, we investigated if vasculogenic mimicry phenomenon of intratumor angiogenesis exists in this tumor type. Paraffin-embedded tissue samples from 21 female dogs with mammary cancers were immunostained for CD31 and Ki-67 nuclear proliferation marker, using Dako LSAB (Labelled streptavidin biotin)+System-HRP (Horseradish Peroxidase). Vasculogenic mimicry pattern was detected where necessary by double staining procedure. Statistical analysis was performed in Statistica software, p<0.05. We obtained a progressive increase of IMD (intratumor microvessel density) in poorly differentiated mammary carcinomas with high proliferative rate, comparing with differentiated ones (p<0.0001). The occurrence of blood channels was higher in vicinity of intratumor necrotic areas. Vasculogenic mimicry was observed more often in tumors with reduced stroma and numerous cancerous cells (such as solid mammary carcinomas), and in poorly differentiated canine mammary cancer. There was a statistical correlation between VM (vasculogenic mimicry) incidence and tumoral grade (p<0.0001). An increased incidence of VM was noticed in canine mammary carcinomas with high rate of intratumoral neo-angiogenesis showed by elevated IMD values (p<0.0007). Evaluation of neo-angiogenesis represents an additional factor that promotes the aggressiveness of canine mammary tumors, allowing the selection of a group of tumors with an aggressive behavior that generate vascular channels which facilitate tumor perfusion.

Keywords: angiogenesis,immunohistochemistry,PAS reaction,vasculogenic mimicry

Download full text PDF
(1312 KB)

Gal AF, Baba AI, Miclaus V, Titilincu A, Cuc C, Taulescu M, et al. Aspects regarding intratumor angiogenesis and vasculogenic mimicry in canine mammary tumors. Rev Romana Med Lab. 2011;19(3):289-302