RRML - Diffuse large B-cell lymphoma – a new look and old prognostic factors

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Nr. 20(4)/2012

Diffuse large B-cell lymphoma – a new look and old prognostic factors

Camelia Dobrea, Hamed Al Salamat, Anca Roxana Lupu

Abstract:

Diffuse large B-cell lymphoma (DLBCL) accounts for about 30% of non-Hodgkin’s lymphoma (NHL) cases. The 2008 WHO Classification of Lymphoid Neoplasms recognizes several clinicopathological variants, subtypes and distinct disease entities of DLBCL. We present a review of clinical, pathological and molecular factors with implication in DLBCL behavior. Even if the golden standard therapy for CD20-positive DLBCL is still represented by R-CHOP, prognostic factor assessment could open new therapeutic perspectives.

Keywords: diffuse large B cell lymphoma,prognostic factors

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Dobrea C, Al Salamat H, Lupu AR. Diffuse large B-cell lymphoma – a new look and old prognostic factors. Rev Romana Med Lab. 2012;20(4):307-15