RRML - Sarcomatoid squamous cell carcinoma of the uterine cervix: immunohistochemistry demonstrates an HPV-related tumor with epithelial origin

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Nr. 20(4)/2012

Sarcomatoid squamous cell carcinoma of the uterine cervix: immunohistochemistry demonstrates an HPV-related tumor with epithelial origin

Gavrilas Muresan, Kinga E Szabo, Laura Bejan, Cristina Marian, Monica Boros, Nicolae Costin, Simona Stolnicu

Abstract:

Sarcomatoid squamous cell carcinoma (SSCS) is a well-documented entity but occurs rarely in the female genital tract, with only 20 reported cases in the uterine cervix. A 72 years old patient was diagnosed with a polypoid 4 cm diameter cervical tumor. Microscopically, the tumor was composed of a poorly differentiated classic keratinizing squamous carcinoma, which was associated with a well-delineated, secondary, extensive and heterogeneous sarcomatoid component. An abrupt transition between the two components was observed, with no zones of gradual transition. The positivity of the sarcoma-like component for epithelial markers (CAM5.2, AE1/AE3, CK5/6) and p16 favors a common epithelial squamous origin of both components of the lesion and an association with HPV- infection. This diagnostic immunophenotype excluded other malignant cervical tumors with a true mesenchymal component that may have different treatment and prognosis.

Keywords: sarcomatoid squamous cell carcinoma,cervix

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Muresan G, Szabo KE, Bejan L, Marian C, Boros M, Costin N, et al. Sarcomatoid squamous cell carcinoma of the uterine cervix: immunohistochemistry demonstrates an HPV-related tumor with epithelial origin. Rev Romana Med Lab. 2012;20(4):383-8