RRML - Inhibition of Streptococcus pneumoniae adenylate kinase by some 5-arylidene-thiazolidin-4-on-2-thione derivates
AMLR

ISSN online: 2284-5623

ISSN-L: 1841-6624

Rejection rate (2020): 75%

Română English


Journal Metrics

Impact Factor 0.493
Five Year Impact Factor 0.531
SNIP 0.373
JCI 0.17


Advanced search


Top 10 downloaded articles
- January 2023 -
 
Romanian Review of Laboratory ... 16
Setting up an own laboratory p... 13
High DNAJA4 expression correla... 12
Downregulation of hsa-miR-4328... 11
Normality assessment, few para... 11
Invasive aspergillosis in hema... 10
Making the most out of profici... 9
Vitamin K and bone metabolism... 8
Oxidative stress and metabolic... 8
Spontaneous atrial fibrillatio... 7

Log in

Concept, Design & Programming
Dr. Adrian Man

   
 
Nr. 21(1)/2013 DOI:10.2478/rrlm-2013-0022
XML
TXT

Inhibition of Streptococcus pneumoniae adenylate kinase by some 5-arylidene-thiazolidin-4-on-2-thione derivates

Mihaela I. Ionescu, Adriana Z. Costache, Ovidiu Oniga, HoriaL. Banciu, Iulia Lupan


Abstract:

Adenylat kinase is an ubiquitous enzyme found in prokaryotes and eukaryotes. In the present study we examined the inhibition of Streptococcus pneumoniae adenylate kinase (AKSP) by six 5-arylidene-thiazolidin-4-on-2-thione derivates using 2, 4-dinitrophenylhydrazine colorimetric assay. Inhibition of AKSP activity with synthetic compounds was performed against recombinant enzyme over-expressed in E. coli. The compound C10H6BrNOS2 with the bromine atom in –ortho position has shown the most efficient inhibitory activity; I50 value (the inhibitor concentration that leads to 50% activity inhibition) was 0.067mM.

Keywords: adenylate kinase,5-arylidene-thiazolidin-4-on-2-thione derivates,inhibitory activity

 
  PDF Download full text PDF
(271 KB)
     
 
How to cite
Ionescu MI, Costache AZ, Oniga O, Banciu H, Lupan I. Inhibition of Streptococcus pneumoniae adenylate kinase by some 5-arylidene-thiazolidin-4-on-2-thione derivates. Rev Romana Med Lab. 2013;21(1):93-9. DOI:10.2478/rrlm-2013-0022