RRML - Study regarding the use of salivary 8‑hydroxideoxyguanosine and Interleukin-1 gene polymorphism - as potential biomarkers in the diagnosis of aggressive periodontitis

Main page
News
RJLabM Credits
Archive
- Current issue
- Ahead of print
- List of published issues
- 2024
  - Nr.1/2024
- 2023
  - Nr.4/2023
  - Nr.3/2023
  - Nr.2/2023
  - Nr.1/2023
  - Supplement 1/2023
- 2022
  - Nr.4/2022
  - Nr.3/2022
  - Nr.2/2022
  - Nr.1/2022
  - Supplement 1/2022
- 2021
  - Nr.4/2021
  - Nr.3/2021
  - Nr.2/2021
  - Nr.1/2021
- 2020
  - Nr.4/2020
  - Nr.3/2020
  - Nr.2/2020
  - Nr.1/2020
  - Supplement 1/2020
- 2019
  - Nr.4/2019
  - Nr.3/2019
  - Nr.2/2019
  - Nr.1/2019
  - Supplement 1/2019
- 2018
  - Nr.4/2018
  - Nr.3/2018
  - Nr.2/2018
  - Nr.1/2018
  - Supplement 1/2018
  - Supplement 2/2018
  - Supplement 3/2018
- 2017
  - Nr.4/2017
  - Nr.3/2017
  - Nr.2/2017
  - Nr.1/2017
  - Supplement 1/2017
- 2016
  - Nr.4/2016
  - Nr.3/2016
  - Nr.2/2016
  - Nr.1/2016
  - Supplement 1/2016
- 2015
  - Nr.4/2015
  - Nr.3/2015
  - Nr.2/2015
  - Nr.1/2015
  - Supplement 1/2015
- 2014
  - Nr.4/2014
  - Nr.3/2014
  - Nr.2/2014
  - Nr.1/2014
  - Supplement 1/2014
- 2013
  - Nr.4/2013
  - Nr.3/2013
  - Nr.2/2013
  - Nr.1/2013
  - Supplement 1/2013
- 2012
  - Nr.4/2012
  - Nr.3/2012
  - Nr.2/2012
  - Nr.1/2012
  - Supplement 1/2012
- 2011
  - Nr.4/2011
  - Nr.3/2011
  - Nr.2/2011
  - Nr.1/2011
  - Supplement 1/2011
- 2010
  - Nr.4/2010
  - Nr.3/2010
  - Nr.2/2010
  - Nr.1/2010
  - Supplement 1/2010
- 2009
  - Nr.4/2009
  - Nr.3/2009
  - Nr.2/2009
  - Nr.1/2009
  - Supplement 1/2009
- 2008
  - Nr.4/2008
  - Nr.3/2008
  - Nr.2/2008
  - Nr.1/2008
  - Supplement 1/2008
- 2007
  - Nr.4/2007
  - Nr.3/2007
  - Nr.2/2007
  - Nr.1/2007
- 2006
  - Nr.4/2006
  - Nr.3/2006
  - Nr.2/2006
  - Nr.1/2006
- 2005
  - Nr.1/2005
Instructions for authors
Online applications
- Send an article
- Online payments
Editorial
About us
Links

ISSN online: 2284-5623

ISSN-L: 1841-6624

Rejection rate (2020): 75%

Journal Metrics

Impact Factor 0.5
Five Year Impact Factor 0.5
JCI 0.12

Top 10 downloaded articles - April 2024 -

A comprehensive review of Prof...	23
Recomandarea comună EFLM-COLA...	12
Understanding the pathogenesis...	7
Monocyte to high-density lipop...	7
Understanding the key differen...	6
Anti-thyroid peroxidase (TPO) ...	6
Predictive value of expression...	5
Romanian Review of Laboratory ...	4
Function of the S1P pathway in...	4
The importance of tumor marker...	3

Concept, Design & Programming
Dr. Adrian Man

Nr. 21(1)/2013 DOI:10.2478/rrlm-2013-0020

Study regarding the use of salivary 8‑hydroxideoxyguanosine and Interleukin-1 gene polymorphism - as potential biomarkers in the diagnosis of aggressive periodontitis

Victoria Badea, Mircea Grigorian, Cristina Nucă, Corneliu Amariei, Alina Martinescu, Lavinia Voineagu

Abstract:

The aim of the present study is to explore the use of salivary 8-hydroxideoxyguanosine (8-OHdG) and Interleukin-1 (IL-1) gene polymorphism in the diagnosis of the patients with aggressive periodontitis. The correlation between salivary 8-OHdG level and clinical parameters was analyzed, at the same time as the use of 8-OHdG level and IL-1gene polymorphism in patients with aggressive periodontitis. Eighteen patients suffering from aggressive periodontitis and 18 healthy subjects without any sign of periodontitis were enrolled into the study after clinical examination. The analysis of genetic polymorphism of IL-1 gene was carried out from oral swabs by using the GenoType IL-1 test; the 8-OHdG biomarker was quantified from saliva samples by using an ELISA competition test. The salivary level of 8-OHdG in the control group was 0.70±0.54 ng/mL and in aggressive periodontitis, 6.93±2.90 ng/mL (p<0.001). A positive genotype consisting of allele 2 (Thymine/Thymine) was found with lower prevalence in healthy subjects - 5.56% - when compared to aggressive periodontitis, respectively 72.22 % (p<0.001). Our study demonstrated that the salivary level of the 8-OHdG biomarker and IL-1 gene polymorphism can be used in the evaluation of the oro-dental status at patients with aggressive periodontitis.

Keywords: 8-OHdG,IL-1,saliva,periodontitis

Download full text PDF
(405 KB)

Badea V, Grigorian M, Nucă C, Amariei C, Martinescu A, Voineagu L. Study regarding the use of salivary 8‑hydroxideoxyguanosine and Interleukin-1 gene polymorphism - as potential biomarkers in the diagnosis of aggressive periodontitis. Rev Romana Med Lab. 2013;21(1):75-82. DOI:10.2478/rrlm-2013-0020