RRML - The Role of Prostate-Specific Antigen (PSA) in Prostate Cancer Screening

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Nr. 22(2)/2014 DOI:10.2478/rrlm-2014-0024

The Role of Prostate-Specific Antigen (PSA) in Prostate Cancer Screening

Traian Vasile Constantin, Victor Lucian Mădan, Maria-Magdalena Constantin, Silviu-Horia Morariu, Bogdan Braticevici


Prostate cancer is, after lung cancer, the most common malignant disease diagnosed in the male population. The introduction into the practice used during the 80’s and 90’s of the determination of serum Prostate-Specific Antigen (PSA) levels, as a component of screening for prostate cancer, was a turning point in the medical practice. Due to this enzyme produced exclusively by the prostate gland, the prostate cancer detection rate (in curative, intracapsular stages) improved significantly. Serum PSA is a better predictive factor for prostate cancer (PC) than digital rectal examination or transrectal prostatic ultrasound.

Keywords: Prostate-specific antigen, prostate cancer, benign prostatic hyperplasia

Received: 16.1.2014
Accepted: 1.6.2014
Published: 9.6.2014

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How to cite
Constantin TV, Mădan VL, Constantin MM, Morariu SH, Braticevici B. The Role of Prostate-Specific Antigen (PSA) in Prostate Cancer Screening. Rev Romana Med Lab. 2014;22(2):275-81. DOI:10.2478/rrlm-2014-0024