RRML - The role of neutrophil to lymphocyte ratio in patients with pTa non-muscle invasive bladder cancer

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Dr. Adrian Man

Nr. 28(1)/2020 DOI:10.2478/rrlm-2020-0001

Research article

The role of neutrophil to lymphocyte ratio in patients with pTa non-muscle invasive bladder cancer

Orsolya Mártha, Daniel Balan, Daniel Porav-Hodade, Emőke Drágus, Mihai Dorin Vartolomei, Călin Bogdan Chibelean, Angela Borda, Ákos Pytel, Olivér Árpád Vida

Correspondence should be addressed to: Daniel Balan


Introduction: The peritumoral inflammatory reaction has a substantial importance in the oncologic outcome of bladder cancer (BC). One biomarker proven to be practical and accessible is the NLR (neutrophil-to-lymphocyte ratio) for high risk non-muscle invasive bladder cancer (NMIBC). The aim of the study was to investigate the role of NLR as a prognostic biomarker for disease recurrence, progression and survival of pTa NMIBC. Material and Methods: In our retrospective study we included 54 patients with pTa NMIBC from a total of 235 patients who underwent transurethral resection of bladder tumor (TURBT) during two consecutive years: January 2007 - December 2008 [median follow-up 106 months (interquartile range-IQR 68-116)]. Criteria for inclusion were: primary tumor, low-grade, with NLR available at 2 weeks prior to TURBT. NLR was considered altered if higher than 3. Results: The median age of the patients included was 63 years (IQR 55 - 72). Most of the patients had NLR<3 (37 patients). Median EORTC (European Organization of Research and Treatment of Cancer) Recurrence Score was 4 (IQR 1-6), while EORTC Progression Score was 3 (IQR 0-6), respectively. Recurrence occurred in 8 out of 54 (14.81 %) patients and progression was identified in 2 out of 54 (3.70 %) patients with muscle-invasive BC during follow-up. NLR>3 was not associated with clinical and pathological factors. In multivariable Cox regression analyses NLR as a continuous variable was an independent predictive factor for recurrence. Recurrence-free survival (RFS) Kaplan-Meier analysis did not show a statistical significance between NLR groups: 82.67% vs. 64.12%, p=0.26. Kaplan-Meier analysis showed a lower Progression-free survival (PFS) in the NLR>3 group: 94.12% vs. 100%, p=0.04. During follow-up (106 months) 18 patients deceased with no impact of NLR as a prognostic factor in multivariable analyses. Kaplan-Meier overall survival (OS) analysis showed a 10-year OS of 70.27% in the low NLR group compared with 58.82% in the high NLR group, p=0.45. Conclusion: In this cohort, high NLR was associated with high recurrence rate in patients with Ta NMIBC. In low-risk NMIBC NLR could represent a valid biomarker for clinical usage regarding the intensity of follow-up schedule.

Keywords: neutrophil-to-lymphocyte ratio, non-muscle invasive bladder cancer, transurethral resection of bladder tumor, recurrence-free survival, progression-free survival

Received: 12.8.2019
Accepted: 30.10.2019
Published: 21.11.2019

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How to cite
Mártha O, Balan D, Porav-Hodade D, Drágus E, Vartolomei MD, Chibelean CB, et al. The role of neutrophil to lymphocyte ratio in patients with pTa non-muscle invasive bladder cancer. Rev Romana Med Lab. 2020;28(1):29-38. DOI:10.2478/rrlm-2020-0001