Research article
Association between adiponectin and Adipoq (rs 1501299) gene polymorphism in gestational diabetes mellitus patients
Suat Cakina, Selin Ulu, Fatma Beyazit, Ebru Özen, Emine Sevinç Postacı
Abstract: Introduction: In this study, we seek to determine the association between the polymorphism of the ADIPOQ (rs1501299) gene and adiponectin levels in gestational diabetes mellitus (GDM) patients. Methods: The study participants included 200 pregnant women, 100 healthy subjects as the control group, and 100 having GDM as the case group. The enzyme-linked immunosorbent assay (ELISA) was used to examine adiponectin levels. The polymerase chain reaction-restriction length polymorphism (PCR-RFLP) was also used for genotyping examination. Results: Findings showed that GDM patients had significantly lower serum adiponectin levels (p=0.001). The T/T genotype homozygotes prevalence for rs1501299 polymorphism was significantly lower in GDM patients. (p=0.047). Conclusion: Low serum adiponectin levels are associated with GDM. The T allele of the rs1501299 (+276 G/T) polymorphism of the ADIPOQ gene protects against GDM.
Keywords: gestational diabetes mellitus, adiponectin, polymorphism
Received: 12.1.2023
Accepted: 7.3.2023
Published: 13.3.2023
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