RRML - Acquired von Willebrand disease: from theory to practice. A single center experience

RRML - Acquired von Willebrand disease: from theory to practice. A single center experience - three case reports

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Nr. 24(1)/2016 DOI:10.1515/rrlm-2016-0005

Case series

Acquired von Willebrand disease: from theory to practice. A single center experience - three case reports

Andrei Colită, Carmen Saguna, Andra Costache, Gabriela Borsaru, Raluca Manolache, Ana Maria Ivănescu, Anca Roxana Lupu

Correspondence should be addressed to: Andrei Colită

Abstract:

Acquired von Willebrand disease (AvWD) represents a rare, potentially severe and most likely underdiagnosed category of hemorrhagic syndromes determined by quantitative, qualitative or functional, nonhereditary, alterations of von Willebrand factor (vWF) that occur in the context of various underlying diseases. It is diagnosed mainly in adults, without any personal or familial history of bleeding. The etiopathogeny of AvWD is complex, marked by the intervention of multiple mechanisms, occuring in the evolution of neoplasia, autoimmune disorders, cardiovascular diseases and other conditions. The clinical and laboratory manifestations are similar to the congenital form with mucocutaneous hemorrhage in patients without bleeding history and demonstration of quantitative and/or functional anomalies of vWF. Treatment has two major objectives: control of bleeding and therapy of the underlying condition. As a practical illustration of the theoretical aspects we present 3 clinical cases of AvWD diagnosed in the Colţea Hospital Department of Hematology during the last 10 years.

Keywords: von Willebrand disease acquired

Received: 20.11.2015
Accepted: 9.1.2016
Published: 29.2.2016

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Colită A, Saguna C, Costache A, Borsaru G, Manolache R, Ivănescu AM, et al. Acquired von Willebrand disease: from theory to practice. A single center experience - three case reports. Rev Romana Med Lab. 2016;24(1):93-101. DOI:10.1515/rrlm-2016-0005