RRML - Sarcomatoid squamous cell carcinoma of the uterine cervix: immunohistochemistry demonstrates an HPV-related tumor with epithelial origin
AMLR

ISSN online: 2284-5623

ISSN-L: 1841-6624

Rejection rate (2020): 75%

Română English


Journal Metrics

Impact Factor 0.5
Five Year Impact Factor 0.5
JCI 0.12


Advanced search


Top 10 downloaded articles
- February 2024 -
 
Anti-thyroid peroxidase (TPO) ... 18
Romanian Review of Laboratory ... 17
Recomandarea comună EFLM-COLA... 13
Approaching Risk Management in... 12
Identification of shared hub g... 12
Challenges in prophylactic the... 12
Monocyte to high-density lipop... 9
Atellica CH 930 chemistry anal... 8
Understanding the key differen... 7
Clinical application value of ... 7

Log in

Concept, Design & Programming
Dr. Adrian Man

   
 
Nr. 20(4)/2012
XML
TXT

Sarcomatoid squamous cell carcinoma of the uterine cervix: immunohistochemistry demonstrates an HPV-related tumor with epithelial origin

Gavrilas Muresan, Kinga E Szabo, Laura Bejan, Cristina Marian, Monica Boros, Nicolae Costin, Simona Stolnicu


Abstract:

Sarcomatoid squamous cell carcinoma (SSCS) is a well-documented entity but occurs rarely in the female genital tract, with only 20 reported cases in the uterine cervix. A 72 years old patient was diagnosed with a polypoid 4 cm diameter cervical tumor. Microscopically, the tumor was composed of a poorly differentiated classic keratinizing squamous carcinoma, which was associated with a well-delineated, secondary, extensive and heterogeneous sarcomatoid component. An abrupt transition between the two components was observed, with no zones of gradual transition. The positivity of the sarcoma-like component for epithelial markers (CAM5.2, AE1/AE3, CK5/6) and p16 favors a common epithelial squamous origin of both components of the lesion and an association with HPV- infection. This diagnostic immunophenotype excluded other malignant cervical tumors with a true mesenchymal component that may have different treatment and prognosis.

Keywords: sarcomatoid squamous cell carcinoma,cervix

 
  PDF Download full text PDF
(897 KB)
     
 
How to cite
Muresan G, Szabo KE, Bejan L, Marian C, Boros M, Costin N, et al. Sarcomatoid squamous cell carcinoma of the uterine cervix: immunohistochemistry demonstrates an HPV-related tumor with epithelial origin. Rev Romana Med Lab. 2012;20(4):383-8