RRML - Abnormalities in soluble CD147 / MMPs / TIMPs axis in Ankylosing Spondylitis patients with and without a history of Acute Anterior Uveitis
AMLR

ISSN online: 2284-5623

ISSN-L: 1841-6624

Rejection rate (2020): 75%

Română English


Journal Metrics

Impact Factor 0.5
Five Year Impact Factor 0.5
JCI 0.12


Advanced search


Top 10 downloaded articles
- June 2024 -
 
The evaluation of a diagnostic... 13
A comprehensive review of Prof... 13
Assessment of ocrelizumab impa... 9
Monitoring the sensitivity of ... 8
Challenges in prophylactic the... 8
Diagnostic value of stress myo... 8
Romanian Review of Laboratory ... 7
Effect of Systemic Inflammator... 7
Understanding the pathogenesis... 6
Evaluation of routine laborato... 6

Log in

Concept, Design & Programming
Dr. Adrian Man

   
 
Nr. 22(4)/2014 DOI:10.2478/rrlm-2014-0039
XML
TXT

Abnormalities in soluble CD147 / MMPs / TIMPs axis in Ankylosing Spondylitis patients with and without a history of Acute Anterior Uveitis

Traian Costin Mitulescu, Liliana Mary Voinea, Denisa Predeteanu, Leontina Mirela Banica, Crina Stavaru, Cristiana Matache


Abstract:

Ankylosing Spondylitis (AS) is the prototype of the axial form of spondyloarthritis. Despite extensive studies, complex mechanisms related to abnormal cellular and molecular processes in AS are not completely understood. Among proinflammatory mediators such as proinflammatory cytokines, NOS-2, chemokines, which lead to inflammation, matrix metalloproteinases (MMPs) play an important role in inflammatory processes that characterize AS. Therefore, we purposed to evaluate whether the disruption of extracellular MMPs inducer (EMMPRIN/CD147), MMPs and tissue inhibitors of MMPs (TIMPs) homeostasis play a role in the evolution of AS especially in patients with a history of Acute Anterior Uveitis (AAU). For this purpose sera from AS patients and from healthy donors (HDs) were assessed for soluble CD147 (sCD147), MMP-3 and TIMP-1 levels using enzyme-linked immunosorbent assay and for the activity of MMP-2 and -9 gelatinases by gelatin zymography. The experimental results showed that the levels of sCD147, MMP-3 and TIMP-1 were significantly increased in AS patients compared to HDs. sCD147 as well as the ratio MMP-2/sCD147 differentiated AS patients with a history of AAU from those without it. The ratios MMP-2/sCD147, MMP-3/sCD147 and MMP-3/TIMP-1 suggested an imbalance between MMPs and their regulators in AS patients. These results suggest that MMPs/sCD147 ratios could be potential biomarkers to strengthen the characterization of AS patients and to predict disease evolution. Positive or negative correlations between some of the experimental and/or clinical features of AS patients and the therapy also highlight the usefulness of the evaluation of these biomarkers to identify an individualized and efficient therapy.

Keywords: Ankylosing Spondylitis, Acute Anterior Uveitis, soluble CD147, MMPs, TIMPs

Received: 12.6.2014
Accepted: 1.11.2014
Published: 16.11.2014

 
  PDF Download full text PDF
(862 KB)
     
 
How to cite
Mitulescu TC, Voinea LM, Predeteanu D, Banica LM, Stavaru C, Matache C. Abnormalities in soluble CD147 / MMPs / TIMPs axis in Ankylosing Spondylitis patients with and without a history of Acute Anterior Uveitis. Rev Romana Med Lab. 2014;22(4):479-96. DOI:10.2478/rrlm-2014-0039