RRML - TNF-α Gene Polymorphisms and Primary Open Angle Glaucoma in Romanian Population

ISSN online: 2284-5623

ISSN-L: 1841-6624

Rejection rate (2020): 75%

Română English

Journal Metrics

Impact Factor 0.5
Five Year Impact Factor 0.5
JCI 0.12

Advanced search

Top 10 downloaded articles
- June 2024 -
The evaluation of a diagnostic... 13
A comprehensive review of Prof... 13
Assessment of ocrelizumab impa... 9
Monitoring the sensitivity of ... 8
Challenges in prophylactic the... 8
Diagnostic value of stress myo... 8
Romanian Review of Laboratory ... 7
Effect of Systemic Inflammator... 7
Understanding the pathogenesis... 6
Evaluation of routine laborato... 6

Log in

Concept, Design & Programming
Dr. Adrian Man

Nr. 23(1)/2015 DOI:10.1515/rrlm-2015-0004

TNF-α Gene Polymorphisms and Primary Open Angle Glaucoma in Romanian Population

Ruxandra Simionescu, Alina Popa Cherecheanu, Liliana Voinea, Roxana Sfrenț-Cornățeanu


Primary open-angle glaucoma (POAG) represents the most common form of a heterogeneous group of glaucomatous optic neuropathies which are a worldwide cause of irreversible blindness. Immune dysregulation and the genetic background are considered important risk factors. The influence on susceptibility to POAG of single nucleotide polymorphisms (SNPs) of tumor necrosis factor-α (TNF-α) was intensively studied, mostly on Asian population. We investigated the possible association of two TNF-α SNPs (-308G/A and -857C/T) with susceptibility to POAG and its clinical characteristics. A case-control association study of aforementioned TNF-α SNPs was performed on 197 POAG patients (divided into two subgroups: high-tension and normal-tension glaucoma - HTG/NTG) versus 208 ethnically matched controls. This is the first study performed on Romanian population. No significant differences were found in terms of allelic frequencies, genotype distribution of the studied SNPs, or their haplotypes between POAG and healthy control groups. In the subgroup analysis, TT genotype of TNF-α -857T-allele was found to be associated with higher values of central corneal thickness (CCT) in NTG subgroup (p-value 0.032). In order to confirm the association between -857C/T SNP of TNF-α and CCT in NTG subgroup of POAG patients, additional studies on different populations should be performed.

Keywords: TNF-α polymorphisms;primary open-angle glaucoma;central corneal thickness

Received: 27.10.2014
Accepted: 29.1.2015
Published: 24.2.2015

  PDF Download full text PDF
(339 KB)
How to cite
Simionescu R, Popa Cherecheanu A, Voinea L, Sfrenț-Cornățeanu R. TNF-α Gene Polymorphisms and Primary Open Angle Glaucoma in Romanian Population. Rev Romana Med Lab. 2015;23(1):47-58. DOI:10.1515/rrlm-2015-0004