RRML - Pitfalls in hemostasis exploration, a case report of a girl with Henoch-Schönlein type vasculitis
AMLR

ISSN online: 2284-5623

ISSN-L: 1841-6624

Rejection rate (2020): 75%

Română English


Journal Metrics

Impact Factor 0.5
Five Year Impact Factor 0.5
JCI 0.12


Advanced search


Top 10 downloaded articles
- March 2024 -
 
Association of betaine-homocys... 2
Improvement of total antioxida... 1
Tissue protection immunohistoc... 1
Anticoagulant mechanisms are m... 1
Changes in the erythrocyte mem... 1
Severe adverse reactions to bl... 1
Screening for common cystic fi... 1
Laboratory techniques in multi... 1
Interdisciplinary correlations... 1
Platelet function monitoring t... 1

Log in

Concept, Design & Programming
Dr. Adrian Man

   
 
Nr. 25(3)/2017 DOI:10.1515/rrlm-2017-0026
XML
TXT

Case report

Pitfalls in hemostasis exploration, a case report of a girl with Henoch-Schönlein type vasculitis

Smaranda Arghirescu, Eugen Boia, Emilia Ursu, Delia Savescu, Madalina Boc, Cristian Jinca, Margit Serban

Correspondence should be addressed to: Margit Serban

Abstract:

The adequate performance and correct interpretation of assays for coagulation factor inhibitors play a critical role for the hemostasis laboratory. Both, false positive and false negative inhibitor assays may be reported, leading to erroneous patient’s management. Therefore, we decided to present a case with a spurious image of an exceptionally rare acquired combined haemophilia A, B and C, with severe factor (F) VIII, IX and XI deficiency, associated with high titre anti - F VIII, IX and XI inhibitors in a 4 years old girl with Henoch-Schönlein type vasculitis. Finally, performing, beside coagulometric methods also antigenic ELISA assays, we had to invalidate the diagnosis. The performance of antiphospholipd antibodies clarified the diagnosis , finally concluding as definite diagnosis Transient Lupus Anticoagulant Syndrome, with decisive impact on therapy and follow-up.

Keywords: acquired haemophilia, lupus anticoagulant, Henoch-Schönlein vasculitis, children, antiphospholipid antibody syndrome

Received: 4.5.2017
Accepted: 10.7.2017
Published: 10.7.2017

 
  PDF Download full text PDF
(317 KB)
     
 
How to cite
Arghirescu S, Boia E, Ursu E, Savescu D, Boc M, Jinca C, et al. Pitfalls in hemostasis exploration, a case report of a girl with Henoch-Schönlein type vasculitis. Rev Romana Med Lab. 2017;25(3):295-300. DOI:10.1515/rrlm-2017-0026