RRML - Could fibrinogen and hsCRP be useful for assessing personal risk in workers exposed to a mixture of ultrafine particles and organic solvents?
AMLR

ISSN online: 2284-5623

ISSN-L: 1841-6624

Rejection rate (2020): 75%

Română English

Journal Metrics

Impact Factor 0.5
Five Year Impact Factor 0.5
JCI 0.12

Advanced search

Top 10 downloaded articles
- April 2024 -
 
A comprehensive review of Prof... 25
Recomandarea comună EFLM-COLA... 15
Anti-thyroid peroxidase (TPO) ... 11
Understanding the key differen... 10
Monocyte to high-density lipop... 10
Romanian Review of Laboratory ... 7
Approaching Risk Management in... 7
Understanding the pathogenesis... 7
Predictive value of expression... 7
Function of the S1P pathway in... 6

Log in

Concept, Design & Programming
Dr. Adrian Man
   
 
Nr. 26(2)/2018 DOI:10.2478/rrlm-2018-0011
XML
TXT

Research article

Could fibrinogen and hsCRP be useful for assessing personal risk in workers exposed to a mixture of ultrafine particles and organic solvents?

Septimiu Voidazan, Horatiu Moldovan, Adina Huţanu, Doina Giurgiu, Stelian Morariu, Lode Godderis, Radu-Corneliu Duca

Correspondence should be addressed to: Horatiu Moldovan

Abstract:

Purpose: Our study focuses on elucidating if two common inflammatory biomarkers, easily performed in any laboratory - high-sensitivity C-reactive protein (hsCRP), as well as fibrinogen - could be used to assess the personal health risk of workers exposed to a complex occupational exposure to ultrafine particles (UFP) and a mixture of organic solvents. Methods: To assess the inflammatory response on the body, laboratory determinations were performed by testing the serum levels of hsCRP and fibrinogen, in exposed and unexposed groups. Results: There are no statistically significant differences for hsCRPs (p-0.25), medians were similar in groups. The mean values of fibrinogen in the three groups were: in the workers group (1st group): 346.2 mg/dl, in the office staff group (2nd group): 328.7 mg/dl, and in the control group (3rd group): 284.8 mg/dl, with significant differences between 1st group vs 3rd group and between 2nd group vs 3rd group (p-0.002). UFP levels differ between the groups, as follows: 1st group were exposed to the highest levels, ranging from 48349 to 3404000 part/cm3; 2nd group, ranging from 17371 to 40595 part/cm3; and 3rd group, ranging from 213 to 16255 part/cm3. Conclusions: Our study demonstrates that fibrinogen is a useful inflammatory biomarker for exposure to a mixture of UFP and organic solvents. On the other hand, hsCRP is not a useful inflammatory biomarker in occupational exposure to UFP and organic solvents. Further studies are needed to demonstrate the extent to which fibrinogen is more or less influenced by organic solvents or UFP alone.

Keywords: ultrafine particles, solvents, occupational exposure, fibrinogen, high-sensitivity C-reactive protein

Received: 21.11.2017
Accepted: 4.3.2018
Published: 28.3.2018

 
  PDF Download full text PDF
(475 KB)
     
 
How to cite
Voidazan S, Moldovan H, Huţanu A, Giurgiu D, Morariu S, Godderis L, et al. Could fibrinogen and hsCRP be useful for assessing personal risk in workers exposed to a mixture of ultrafine particles and organic solvents?. Rev Romana Med Lab. 2018;26(2):177-87. DOI:10.2478/rrlm-2018-0011