RRML - Association between adiponectin and Adipoq (rs 1501299) gene polymorphism in gestational diabetes mellitus patients

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Nr. 31(2)/2023 DOI:10.2478/rrlm-2023-0010

Research article

Association between adiponectin and Adipoq (rs 1501299) gene polymorphism in gestational diabetes mellitus patients

Suat Cakina, Selin Ulu, Fatma Beyazit, Ebru Özen, Emine Sevinç Postacı

Correspondence should be addressed to: Suat Cakina

Abstract:

Introduction: In this study, we seek to determine the association between the polymorphism of the ADIPOQ (rs1501299) gene and adiponectin levels in gestational diabetes mellitus (GDM) patients. Methods: The study participants included 200 pregnant women, 100 healthy subjects as the control group, and 100 having GDM as the case group. The enzyme-linked immunosorbent assay (ELISA) was used to examine adiponectin levels. The polymerase chain reaction-restriction length polymorphism (PCR-RFLP) was also used for genotyping examination. Results: Findings showed that GDM patients had significantly lower serum adiponectin levels (p=0.001). The T/T genotype homozygotes prevalence for rs1501299 polymorphism was significantly lower in GDM patients. (p=0.047). Conclusion: Low serum adiponectin levels are associated with GDM. The T allele of the rs1501299 (+276 G/T) polymorphism of the ADIPOQ gene protects against GDM.

Keywords: gestational diabetes mellitus, adiponectin, polymorphism

Received: 12.1.2023
Accepted: 7.3.2023
Published: 13.3.2023

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Cakina S, Ulu S, Beyazit F, Özen E, Postacı ES. Association between adiponectin and Adipoq (rs 1501299) gene polymorphism in gestational diabetes mellitus patients. Rev Romana Med Lab. 2023;31(2):119-24. DOI:10.2478/rrlm-2023-0010