RRML - Reciprocal antagonism between inflammation and the protein C system

ISSN online: 2284-5623

ISSN-L: 1841-6624

Rejection rate (2020): 75%

Română English

Journal Metrics

Impact Factor 0.5
Five Year Impact Factor 0.5
JCI 0.12

Advanced search

Top 10 downloaded articles
- December 2023 -
Romanian Review of Laboratory ... 3
The potential of programmed de... 3
Chronic lymphocytic leukemia d... 2
Hepcidin: a crucial peptide fo... 2
The Omega-3 Index and The Risk... 2
Glycemic control and dyslipide... 2
Comparison of two analytical m... 2
Gout, hyperuricemia and the me... 2
Determining hemoglobin referen... 2
Retraction of article: Short t... 2

Log in

Concept, Design & Programming
Dr. Adrian Man

Nr. 21(2)/2013 DOI:10.2478/rrlm-2013-0003

Reciprocal antagonism between inflammation and the protein C system

Mircea Cucuianu, Ioana Brudasca, Luminita Plesca, Gyorgy Bodizs, Dan Colhon, Andrei Cucuianu


Protein C is a vitamin K-dependent serine protease secreted by the hepatocytes as an inactive zymogen and activated by thrombin bound to endothelial thrombomodulin. An endothelial protein C receptor (EPCR) is involved in both activation and enhancement of protein C activity, resulting in proteolytic degradation of clot-ting factors Va and VIIIa, thereby providing an efficient anticoagulant mechanism. Evidence was also provided that proinflammatory cytokines would impair the endothelia-mediated activation and activity of the Protein C system by inducing an internalization and proteolytic degradation of thrombomodulin and by shedding EPCR from the surface of endothelial cells membrane. Clinical and experimental studies also emphasized that an inflammatory acute phase reaction is accompanied by a commuted hepatic protein synthesis leading to an in-crease of plasma fibrinogen, factor VIII:C and of α1 protease inhibitor, while the plasma level of protein C zymogen decrease. On the other hand infusions of activated protein C were reported to protect from a toxico-septic shock by exerting not only anticoagulant but also anti-inflammatory effects.

Keywords: Protein C,thrombomodulin,endothelial protein C receptor,inflammation-dependent depressive effects,thera-peutic approach with activated protein C

  PDF Download full text PDF
(717 KB)
How to cite
Cucuianu M, Brudasca I, Plesca L, Bodizs G, Colhon D, Cucuianu A. Reciprocal antagonism between inflammation and the protein C system. Rev Romana Med Lab. 2013;21(2):129-33. DOI:10.2478/rrlm-2013-0003